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Human fibroblast growth factor - 1 (FGF-1) mutant S116R

Analyse Human fibroblast growth factor - 1 (FGF-1) mutant S116R in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4XKI
Type: protein
Length: 289 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fibroblast growth factor 1
UniProt: P05230
Ligands: PO4, SO4
Pockets: 3 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fibroblast growth factor 1	protein	145	8% helix, 37% strand	P05230
B	Fibroblast growth factor 1	protein	144	8% helix, 38% strand	P05230

Ligands and binding sites

PO4 · Phosphate ion · ion · 8 copies · chains A, B
SO4 · Sulfate ion · ion · 2 copies · chains A
GOL · Glycerol · additive · chains A, B
2PE · Nonaethylene glycol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	220	0.63	0.82	40	empty
2	197	0.56	0.79	28	empty
3	133	0.54	0.81	30	2PE

Interfaces

1 interface between chains.

A–B · 531 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4XKI · Human Fibroblast Growth Factor - 1 (FGF-1) mutant S116R · the same entry in another collection · chain A against A, TM-score 1.00
P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05230
Elsewhere: RCSB PDB 4XKI · PDBe 4XKI · UniProt P05230

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