Research workbench
Complement component C4B
Analyse Complement component C4B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XAM
- Type
- protein
- Length
- 3,128 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement C4 beta chain; Complement C4-a alpha chain; Complement C4 gamma chain
- UniProt
- P0C0L4
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 17% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Complement C4 beta chain | protein | 651 | 6% helix, 47% strand | P0C0L4 |
| C, E | Complement C4-a alpha chain | protein | 632 | 30% helix, 21% strand | P0C0L4 |
| D, F | Complement C4 gamma chain | protein | 281 | 11% helix, 38% strand | P0C0L4 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 248 | 0.82 | 0.94 | 52 | empty |
| 2 | 252 | 0.81 | 0.93 | 52 | empty |
| 3 | 73 | 0.75 | 0.98 | 30 | empty |
| 4 | 72 | 0.74 | 0.97 | 29 | empty |
| 5 | 67 | 0.72 | 0.97 | 20 | empty |
Interfaces
9 interfaces between chains.
- A–C · 5031 Ų buried · 83 hydrogen bonds · protein-protein
- B–E · 4993 Ų buried · 74 hydrogen bonds · protein-protein
- C–D · 2573 Ų buried · 35 hydrogen bonds · protein-protein
- E–F · 2528 Ų buried · 34 hydrogen bonds · protein-protein
- B–F · 821 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
- P0C0L4 · AlphaFold monomer V2.0 prediction for complement C4-a (P0C0L4) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C0L4
- Elsewhere: RCSB PDB 4XAM · PDBe 4XAM · UniProt P0C0L4
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