UniProt P0C0L4
Complement C4 beta chain (P0C0L4)
Complement C4 beta chain (UniProt P0C0L4): 15 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 71 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0C0L4
- Protein
- Complement C4 beta chain
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 71 · 4 records with a druggable one
Structures
16 records of P0C0L4 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4FXG | Complement C4 in complex with masp-2 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4FXK | Human complement C4 | x-ray diffraction | A, B, C | — | — |
| 4XAM | Complement component C4B | x-ray diffraction | A, C, D, B, E, F | — | — |
| 5JPM | Structure of the complex of human complement C4 with masp-2 rebuilt using imdff | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5JPN | Structure of human complement C4 rebuilt using imdff | x-ray diffraction | A, B, C | — | — |
| 5JTW | Crystal structure of complement C4b re-refined using iMDFF | x-ray diffraction | A, B, C, D, E, F | NAG | — |
| 5JTW | Crystal structure of complement C4B re-refined using imdff | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6YSQ | The hC4Nb8 complement inhibitory nanobody in complex with C4b | x-ray diffraction | A, C, B, D | NAG | 20 (best 0.80) |
| 6YSQ | The HC4NB8 complement inhibitory nanobody in complex with C4B | x-ray diffraction | A, C, B, D | NAG | — |
| 7B2M | Cryo-EM structure of complement C4b in complex with nanobody E3 | electron microscopy | A, B, C | NAG | 18 (best 0.73) |
| 7B2M | Cryo-EM structure of complement C4B in complex with nanobody E3 | electron microscopy | A, B, C | NAG | — |
| 7B2P | Cryo-EM structure of complement C4b in complex with nanobody B5 | electron microscopy | A, B, C | NAG | 19 (best 0.75) |
| 7B2P | Cryo-EM structure of complement C4B in complex with nanobody B5 | electron microscopy | A, B, C | NAG | — |
| 7B2Q | Cryo-EM structure of complement C4b in complex with nanobody B12 | electron microscopy | A, B, C | NAG | 14 (best 0.70) |
| 7B2Q | Cryo-EM structure of complement C4B in complex with nanobody B12 | electron microscopy | A, B, C | NAG | — |
| P0C0L4 | AlphaFold monomer V2.0 prediction for complement C4-a (P0C0L4) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 9 records
Experiment against prediction
- 6YSQ chain B against the predicted model P0C0L4: TM-score 0.99, RMSD 0.89 Å
- 6YSQ chain B against the predicted model P0C0L4: TM-score 0.99, RMSD 0.89 Å
- 6YSQ chain A against the predicted model P0C0L4: TM-score 0.99, RMSD 0.97 Å
- 6YSQ chain A against the predicted model P0C0L4: TM-score 0.99, RMSD 0.97 Å
- 7B2P chain A against the predicted model P0C0L4: TM-score 0.99, RMSD 0.94 Å
- 7B2P chain A against the predicted model P0C0L4: TM-score 0.99, RMSD 0.94 Å
- 7B2M chain A against the predicted model P0C0L4: TM-score 0.99, RMSD 0.98 Å
- 7B2M chain A against the predicted model P0C0L4: TM-score 0.99, RMSD 0.98 Å
- 7B2Q chain A against the predicted model P0C0L4: TM-score 0.99, RMSD 1.02 Å
- 7B2Q chain A against the predicted model P0C0L4: TM-score 0.99, RMSD 1.02 Å
Elsewhere
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