Research workbench
Crystal structure of the coiled-coil surrounding skip 3 of MYH7
Analyse Crystal structure of the coiled-coil surrounding skip 3 of MYH7 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XA4
- Type
- protein
- Length
- 399 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- XRCC4-MYH7(1551-1609) chimera protein
- UniProt
- Q13426, P12883
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | XRCC4-MYH7(1551-1609) chimera protein | protein | 200 | 52% helix, 28% strand | Q13426, P12883 |
| B | XRCC4-MYH7(1551-1609) chimera protein | protein | 199 | 53% helix, 26% strand | Q13426, P12883 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 155 | 0.43 | 0.74 | 27 | empty |
| 2 | 138 | 0.41 | 0.75 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 2543 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 4XA4 · Crystal Structure of the coiled-coil surrounding Skip 3 of MYH7 · the same entry in another collection · chain A against A, TM-score 1.00
- Q13426 · AlphaFold monomer V2.0 prediction for DNA repair protein XRCC4 (Q13426) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P12883 · AlphaFold monomer V2.0 prediction for myosin-7 (P12883) · a predicted model of the same protein · chain A against A, TM-score 0.52
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13426
- Every structure of UniProt P12883
- Elsewhere: RCSB PDB 4XA4 · PDBe 4XA4 · UniProt Q13426 · UniProt P12883
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