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Mycobacterium tuberculosis rbpa-sid in complex with sigmaa domain 2

Analyse Mycobacterium tuberculosis rbpa-sid in complex with sigmaa domain 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
4X8K
Type
protein
Length
154 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
RNA polymerase sigma factor siga; RNA polymerase-binding protein rbpa
UniProt
P9WGI0, P9WHJ4
Ligands
SO4

Structure

x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ARNA polymerase sigma factor sigaprotein12278% helix, 0% strandP9WGI0
BRNA polymerase-binding protein rbpaprotein3272% helix, 0% strandP9WHJ4

Ligands and binding sites

  • SO4 · Sulfate ion · ion · 3 copies · chains A, B
  • EDO · 1,2-ethanediol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

  • A–B · 1015 Ų buried · 15 hydrogen bonds · protein-protein

Compared structures

  • 4X8K · Mycobacterium tuberculosis RbpA-SID in complex with SigmaA domain 2 · the same entry in another collection · chain A against A, TM-score 1.00
  • P9WGI0 · AlphaFold monomer V2.0 prediction for RNA polymerase sigma factor siga (P9WGI0) · a predicted model of the same protein · chain A against A, TM-score 0.98
  • P9WHJ4 · AlphaFold monomer V2.0 prediction for RNA polymerase-binding protein rbpa (P9WHJ4) · a predicted model of the same protein · chain B against A, TM-score 0.90

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