Research workbench
Human histidine tRNA synthetase
Analyse Human histidine tRNA synthetase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4X5O
- Type
- protein
- Length
- 784 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histidine--tRNA ligase, cytoplasmic
- EC
- 6.1.1.21
- UniProt
- P12081
- Pockets
- 8 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) | protein | 434 | 39% helix, 20% strand | P12081 |
| B | Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) | protein | 350 | 33% helix, 25% strand | P12081 |
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 662 | 0.81 | 0.85 | 43 | empty |
| 2 | 696 | 0.68 | 0.76 | 56 | empty |
| 3 | 469 | 0.65 | 0.78 | 45 | empty |
| 4 | 191 | 0.52 | 0.77 | 30 | empty |
| 5 | 194 | 0.51 | 0.77 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 4037 Ų buried · 47 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12081
- Elsewhere: RCSB PDB 4X5O · PDBe 4X5O · UniProt P12081
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