UniProt P12081
Histidine--tRNA ligase, cytoplasmic (P12081)
Histidine--tRNA ligase, cytoplasmic (UniProt P12081), EC 6.1.1.21: 16 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P12081
- Protein
- Histidine--tRNA ligase, cytoplasmic
- EC
- 6.1.1.21
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 9 · 1 record with a druggable one
Structures
17 records of P12081 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1X59 | Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase | solution nmr | A | — | — |
| 1X59 | Solution structures of the whep-trs domain of human histidyl-tRNA synthetase | solution nmr | A | — | — |
| 2LW7 | NMR solution structure of human HisRS splice variant | solution nmr | A | — | — |
| 2LW7 | NMR solution structure of human hisrs splice variant | solution nmr | A | — | — |
| 4G84 | Crystal structure of human HisRS | x-ray diffraction | A, B | — | — |
| 4G84 | Crystal structure of human hisrs | x-ray diffraction | A, B | — | — |
| 4G85 | Crystal structure of human HisRS | x-ray diffraction | A, B | — | — |
| 4G85 | Crystal structure of human hisrs | x-ray diffraction | A, B | — | — |
| 4PHC | Crystal Structure of a human cytosolic histidyl-tRNA synthetase, histidine-bound | x-ray diffraction | A, B, C, D | — | — |
| 4PHC | Crystal structure of a human cytosolic histidyl-tRNA synthetase, histidine-bound | x-ray diffraction | A, B, C, D | — | — |
| 4X5O | Human histidine tRNA synthetase | x-ray diffraction | A, B | — | — |
| 4X5O | Human histidine tRNA synthetase | x-ray diffraction | A, B | — | — |
| 5W6M | Crystal structure of the human histidyl-tRNA synthetase mutant D175E | x-ray diffraction | A, B | — | 9 (best 0.82) |
| 5W6M | Crystal structure of the human histidyl-tRNA synthetase mutant D175E | x-ray diffraction | A, B | — | — |
| 6O76 | Human cytosolic Histidyl-tRNA synthetase (HisRS) with WHEP domain | x-ray diffraction | A, B | CL | — |
| 6O76 | Human cytosolic histidyl-tRNA synthetase (hisrs) with whep domain | x-ray diffraction | A, B | CL | — |
| P12081 | AlphaFold monomer V2.0 prediction for histidine--tRNA ligase, cytoplasmic (P12081) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 2 records
Experiment against prediction
- 4G84 chain A against the predicted model P12081: TM-score 0.99, RMSD 0.70 Å
- 4G84 chain A against the predicted model P12081: TM-score 0.99, RMSD 0.70 Å
- 4X5O chain B against the predicted model P12081: TM-score 0.99, RMSD 0.69 Å
- 4X5O chain B against the predicted model P12081: TM-score 0.99, RMSD 0.69 Å
- 5W6M chain B against the predicted model P12081: TM-score 0.99, RMSD 0.78 Å
- 5W6M chain B against the predicted model P12081: TM-score 0.99, RMSD 0.78 Å
- 4G85 chain B against the predicted model P12081: TM-score 0.99, RMSD 0.89 Å
- 4G85 chain B against the predicted model P12081: TM-score 0.99, RMSD 0.89 Å
- 5W6M chain A against the predicted model P12081: TM-score 0.99, RMSD 0.92 Å
- 5W6M chain A against the predicted model P12081: TM-score 0.99, RMSD 0.92 Å
Elsewhere
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