MolNFT v1 · #26958 · protein

Solution structures of the whep-trs domain of human histidyl-tRNA synthetase

1X59: “Solution structures of the whep-trs domain of human histidyl-tRNA synthetase”. Solution nmr, 1 pocket (best druggability 0.27). MolNFT v1 #26958 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1X59
Type: protein
Length: 73 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Histidyl-tRNA synthetase
EC: 6.1.1.21
UniProt: P12081
Pockets: 1 · best druggability 0.27

Structure

solution nmr · 1 distinct chain · 56% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Histidyl-tRNA synthetase (EC 6.1.1.21)	protein	73	56% helix, 0% strand	P12081

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.27	0.74	12	empty

Compared structures

1X59 · Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase · the same entry in another collection · chain A against A, TM-score 1.00
P12081 · AlphaFold monomer V2.0 prediction for histidine--tRNA ligase, cytoplasmic (P12081) · a predicted model of the same protein · chain A against A, TM-score 0.61

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12081
Elsewhere: RCSB PDB 1X59 · PDBe 1X59 · UniProt P12081

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