ULK3 regulates cytokinetic abscission by phosphorylating escrt-III proteins

Structure

x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).

Ligands and binding sites

• CO · Cobalt (II) ion · metal · chains A
• SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–E · 636 Ų buried · 6 hydrogen bonds · protein-protein

Compared structures

• 4WZX · ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins · the same entry in another collection · chain A against A, TM-score 1.00
• Q6PHR2 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase ULK3 (Q6PHR2) · a predicted model of the same protein · chain A against A, TM-score 0.99
• P53990 · AlphaFold monomer V2.0 prediction for IST1 homolog (P53990) · a predicted model of the same protein · chain E against A, TM-score 0.69

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q6PHR2
• Every structure of UniProt P53990
• Elsewhere: RCSB PDB 4WZX · PDBe 4WZX · UniProt Q6PHR2 · UniProt P53990