UniProt P53990
IST1 homolog (P53990)
IST1 homolog (UniProt P53990): 23 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 65 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P53990
- Protein
- IST1 homolog
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 65 · 3 records with a druggable one
Structures
24 records of P53990 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3FRR | Structure of human IST1(NTD) - (residues 1-189)(P21) | x-ray diffraction | A | — | — |
| 3FRR | Structure of human IST1(NTD) - (residues 1-189)(P21) | x-ray diffraction | A | — | — |
| 3FRS | Structure of human IST1(NTD) (residues 1-189)(p43212) | x-ray diffraction | A | — | — |
| 3FRS | Structure of human IST1(NTD) (residues 1-189)(P43212) | x-ray diffraction | A | — | — |
| 3JC1 | Electron cryo-microscopy of the IST1-CHMP1B ESCRT-III copolymer | electron microscopy | Aa, Ac, Ae, Ag, Ai, Ak, Am, Ao, Aq, As, Au, Aw, Ay, Ba, Bc, Be, Bg, Bi, Bk, Bm, Bo, Bq, Bs, Bu, Bw, By, Ca, Cc, Ce, Cg, Ci, Ck, Cm, Co | — | — |
| 4U7E | The crystal structure of the complex of LIP5 NTD and IST1 MIM | x-ray diffraction | A | — | — |
| 4U7E | The crystal structure of the complex of LIP5 ntd and IST1 mim | x-ray diffraction | A | — | — |
| 4U7I | Structure of the complex of Spartin MIT and IST1 MIM | x-ray diffraction | B | — | — |
| 4U7I | Structure of the complex of spartin mit and IST1 mim | x-ray diffraction | B | — | — |
| 4U7Y | Structure of the complex of VPS4B MIT and IST1 MIM | x-ray diffraction | B | — | — |
| 4U7Y | Structure of the complex of VPS4B mit and IST1 mim | x-ray diffraction | B | — | — |
| 4WZX | ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins | x-ray diffraction | E | — | — |
| 4WZX | ULK3 regulates cytokinetic abscission by phosphorylating escrt-III proteins | x-ray diffraction | E | — | — |
| 6E8G | CryoEM reconstruction of IST1-CHMP1B copolymer filament bound to ssDNA at 2.9 Angstrom resolution | electron microscopy | S, A, C, E, G, I, K, M, O, Q, V, X, Z, BA, DA, FA, HA, JA, LA, NA, PA, RA, TA, VA, XA, ZA, BB, DB, FB, HB, JB, LB, NB, PB, RB, TB | — | 20 (best 0.82) |
| 6TZ4 | CryoEM reconstruction of membrane-bound ESCRT-III filament composed of CHMP1B+IST1 (right-handed) | electron microscopy | MB, B, D, F, H, J, L, N, P, R, T, W, Y, AA, CA, EA, GA, IA, KA, MA, OA, QA, SA, UA, WA, YA, AB, CB, EB, GB, IB, KB, OB, QB, SB, 01 | — | — |
| 6TZ5 | CryoEM reconstruction of membrane-bound ESCRT-III filament composed of CHMP1B+IST1 (left-handed) | electron microscopy | BB, DB, FB, HB, JB, LB, NB, PB, TA, VA, XA, ZA, BA, A, DA, FA, HA, JA, LA, NA, PA, RA, C, E, G, I, K, M, O, Q, S, V, X, Z | — | 20 (best 0.82) |
| 6TZA | CryoEM reconstruction of ESCRT-III filament composed of IST1 NTD R16E K27E double mutant | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N | — | 20 (best 0.80) |
| 6TZA | Cryoem reconstruction of escrt-III filament composed of IST1 ntd R16E K27E double mutant | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N | — | — |
| 7S7J | Structure of Human SPASTIN-IST1 complex. | x-ray diffraction | B | CA, CL | — |
| 8UC6 | Calpain-7:IST1 Complex | x-ray diffraction | G, E | — | — |
| 8V2Q | CHMP1B/IST1 ssRNA bound copolymer | electron microscopy | B | — | 1 (best 0.33) |
| 8V2R | CryoEM of ssDNA bound CHMP1B/IST1 copolymer assembly | electron microscopy | B | — | 2 (best 0.35) |
| 8V2S | CHMP1B/IST1 dsDNA bound copolymer | electron microscopy | B | — | 2 (best 0.40) |
| P53990 | AlphaFold monomer V2.0 prediction for IST1 homolog (P53990) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8V2Q chain B against the predicted model P53990: TM-score 0.99, RMSD 0.40 Å
- 8V2S chain B against the predicted model P53990: TM-score 0.99, RMSD 0.43 Å
- 8V2R chain B against the predicted model P53990: TM-score 0.99, RMSD 0.43 Å
- 6E8G chain M against the predicted model P53990: TM-score 0.98, RMSD 0.89 Å
- 6E8G chain JB against the predicted model P53990: TM-score 0.98, RMSD 0.89 Å
- 6E8G chain Z against the predicted model P53990: TM-score 0.98, RMSD 0.89 Å
- 6E8G chain O against the predicted model P53990: TM-score 0.98, RMSD 0.89 Å
- 6E8G chain RA against the predicted model P53990: TM-score 0.98, RMSD 0.89 Å
- 6E8G chain C against the predicted model P53990: TM-score 0.98, RMSD 0.89 Å
- 6E8G chain BB against the predicted model P53990: TM-score 0.98, RMSD 0.89 Å
Elsewhere
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