MolNFT v1 · #165557 · protein
Cryoem reconstruction of escrt-III filament composed of IST1 ntd R16E K27E double mutant
6TZA · IST1 homolog: “Cryoem reconstruction of escrt-III filament composed of IST1 ntd R16E K27E double mutant”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #165557 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6TZA
- Type
- protein
- Length
- 2,534 residues
- Chains
- 14
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IST1 homolog
- UniProt
- P53990
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N | IST1 homolog | protein | 181 | 77% helix, 0% strand | P53990 |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 308 | 0.80 | 0.90 | 45 | empty |
| 2 | 427 | 0.78 | 0.86 | 62 | empty |
| 3 | 476 | 0.77 | 0.85 | 67 | empty |
| 4 | 807 | 0.77 | 0.80 | 105 | empty |
| 5 | 486 | 0.76 | 0.84 | 64 | empty |
Interfaces
16 interfaces between chains.
- C–J · 406 Ų buried · 1 hydrogen bond · protein-protein
- D–E · 405 Ų buried · 2 hydrogen bonds · protein-protein
- G–L · 399 Ų buried · 0 hydrogen bonds · protein-protein
- C–M · 391 Ų buried · 0 hydrogen bonds · protein-protein
- K–M · 390 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6TZA · CryoEM reconstruction of ESCRT-III filament composed of IST1 NTD R16E K27E double mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53990
- Elsewhere: RCSB PDB 6TZA · PDBe 6TZA · UniProt P53990
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