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Crystal structure of the myocilin olfactomedin domain

Analyse Crystal structure of the myocilin olfactomedin domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4WXQ
Type: protein
Length: 259 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myocilin
UniProt: Q99972
Ligands: CA, NA
Pockets: 1 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 4% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myocilin	protein	259	4% helix, 54% strand	Q99972

Ligands and binding sites

CA · Calcium ion · metal · chains A
NA · Sodium ion · metal · chains A
P6G · Hexaethylene glycol · additive · 7 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	189	0.63	0.83	38	P6G

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4WXQ · Crystal Structure of the Myocilin Olfactomedin Domain · the same entry in another collection · chain A against A, TM-score 1.00
Q99972 · AlphaFold monomer V2.0 prediction for myocilin (Q99972) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99972
Elsewhere: RCSB PDB 4WXQ · PDBe 4WXQ · UniProt Q99972

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