Research workbench
Structure of tRNA-processing enzyme with CTP
Analyse Structure of tRNA-processing enzyme with CTP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4WC1
- Type
- protein
- Length
- 714 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Poly a polymerase
- UniProt
- O66728
- Ligands
- CTP
- Pockets
- 9 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 56% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Poly a polymerase | protein | 364 | 57% helix, 11% strand | O66728 |
| B | Poly a polymerase | protein | 350 | 56% helix, 11% strand | O66728 |
Ligands and binding sites
- CTP · Cytidine-5'-triphosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 775 | 0.71 | 0.77 | 54 | empty |
| 2 | 271 | 0.51 | 0.75 | 32 | CTP |
| 3 | 183 | 0.50 | 0.77 | 22 | empty |
| 4 | 94 | 0.50 | 0.82 | 21 | empty |
| 5 | 287 | 0.50 | 0.74 | 31 | CTP |
Interfaces
1 interface between chains.
- A–B · 611 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O66728
- Elsewhere: RCSB PDB 4WC1 · PDBe 4WC1 · UniProt O66728
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