Research workbench
Structure of the wnt deacylase notum - crystal form VI - 2.2A
Analyse Structure of the wnt deacylase notum - crystal form VI - 2.2A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UZ7
- Type
- protein
- Length
- 715 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein notum homolog
- EC
- 3.1.1.1
- UniProt
- Q6P988
- Ligands
- CL
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein notum homolog (EC 3.1.1.1) | protein | 358 | 34% helix, 16% strand | Q6P988 |
| B | Protein notum homolog (EC 3.1.1.1) | protein | 357 | 34% helix, 17% strand | Q6P988 |
Ligands and binding sites
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.74 | 0.94 | 22 | empty |
| 2 | 107 | 0.73 | 0.94 | 22 | empty |
| 3 | 732 | 0.66 | 0.75 | 59 | empty |
| 4 | 74 | 0.32 | 0.75 | 17 | empty |
| 5 | 68 | 0.29 | 0.73 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 317 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 disulfide (disulfide).
Compared structures
- 4UZ7 · Structure of the wnt deacylase notum - crystal form VI - 2.2A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P988
- Elsewhere: RCSB PDB 4UZ7 · PDBe 4UZ7 · UniProt Q6P988
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