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Structure of FLIN2, a complex containing the N-terminal lim domain of LMO2 and LDB1-lid

Analyse Structure of FLIN2, a complex containing the N-terminal lim domain of LMO2 and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1J2O
Type
protein
Length
114 residues
Chains
1
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Fusion of rhombotin-2 and lim domain-binding protein 1
UniProt
P25801, P70662
Ligands
ZN
Pockets
1 · best druggability 0.33

Structure

solution nmr · 1 distinct chain · 7% helix, 15% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AFusion of rhombotin-2 and lim domain-binding protein 1protein1147% helix, 15% strandP25801, P70662

Ligands and binding sites

  • ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1670.330.7616empty

Compared structures

  • 1J2O · Structure of FLIN2, a complex containing the N-terminal LIM domain of LMO2 and ldb1-LID · the same entry in another collection · chain A against A, TM-score 1.00
  • P25801 · AlphaFold monomer V2.0 prediction for rhombotin-2 (P25801) · a predicted model of the same protein · chain A against A, TM-score 0.49
  • P70662 · AlphaFold monomer V2.0 prediction for lim domain-binding protein 1 (P70662) · a predicted model of the same protein · chain A against A, TM-score 0.31

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