Research workbench

Deerpox virus DPV022 in complex with bax BH3

Analyse Deerpox virus DPV022 in complex with bax BH3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4UF2
Type: protein
Length: 155 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antiapoptotic membrane protein; Apoptosis regulator bax
UniProt: Q08FF8, Q07812
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Antiapoptotic membrane protein	protein	136	76% helix, 0% strand	Q08FF8
B	Apoptosis regulator bax	protein	19	68% helix, 0% strand	Q07812

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	371	0.55	0.74	35	empty
2	73	0.33	0.75	13	empty

Interfaces

1 interface between chains.

A–B · 821 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

4UF2 · Deerpox virus DPV022 in complex with Bax BH3 · the same entry in another collection · chain A against A, TM-score 1.00
Q07812 · AlphaFold monomer V2.0 prediction for apoptosis regulator bax (Q07812) · a predicted model of the same protein · chain B against A, TM-score 0.62

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q08FF8
Every structure of UniProt Q07812
Elsewhere: RCSB PDB 4UF2 · PDBe 4UF2 · UniProt Q08FF8 · UniProt Q07812

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