Research workbench
Complex of D. melanogaster EIF4E with EIF4G and cap analog
Analyse Complex of D. melanogaster EIF4E with EIF4G and cap analog in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UEC
- Type
- protein
- Length
- 378 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E; Eukaryotic translation initiation factor 4G…
- UniProt
- P48598, O61380
- Ligands
- MGT
- Pockets
- 8 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Eukaryotic translation initiation factor 4E | protein | 171 | 30% helix, 31% strand | P48598 |
| B | Eukaryotic translation initiation factor 4G, isoform a | protein | 36 | 31% helix, 6% strand | O61380 |
Ligands and binding sites
- MGT · 7N-methyl-8-hydroguanosine-5'-triphosphate · ligand · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 50 | 0.46 | 0.85 | 20 | empty |
| 2 | 82 | 0.41 | 0.78 | 16 | MGT |
| 3 | 94 | 0.40 | 0.77 | 20 | MGT |
| 4 | 69 | 0.39 | 0.79 | 12 | empty |
| 5 | 93 | 0.38 | 0.76 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–C · 874 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 738 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 295 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4UEC · Complex of D. melanogaster eIF4E with eIF4G and cap analog · the same entry in another collection · chain A against A, TM-score 1.00
- P48598 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E1… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48598
- Every structure of UniProt O61380
- Elsewhere: RCSB PDB 4UEC · PDBe 4UEC · UniProt P48598 · UniProt O61380
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