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Structural analysis of the human fibroblast growth factor receptor 4 kinase

Analyse Structural analysis of the human fibroblast growth factor receptor 4 kinase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4TYE
Type: protein
Length: 292 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fibroblast growth factor receptor 4
EC: 2.7.10.1
UniProt: P22455
Ligands: PO4
Pockets: 3 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fibroblast growth factor receptor 4 (EC 2.7.10.1)	protein	292	35% helix, 17% strand	P22455

Ligands and binding sites

PO4 · Phosphate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	239	0.68	0.84	45	empty
2	148	0.40	0.73	25	empty
3	55	0.27	0.73	15	empty

Compared structures

4TYE · Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase · the same entry in another collection · chain A against A, TM-score 1.00
P22455 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 4 (P22455) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22455
Elsewhere: RCSB PDB 4TYE · PDBe 4TYE · UniProt P22455

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