Research workbench
Kutzneria sp. 744 ornithine N-hydroxylase, ktzi-fadox-br
Analyse Kutzneria sp. 744 ornithine N-hydroxylase, ktzi-fadox-br in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4TM3
- Type
- protein
- Length
- 1,656 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ktzi
- UniProt
- A8CF85
- Ligands
- FAD, BR
- Pockets
- 19 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Ktzi | protein | 414 | 32% helix, 24% strand | A8CF85 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 4 copies · chains A, B, C, D
- BR · Bromide ion · ion · 46 copies · chains A, B, D, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 606 | 0.82 | 0.87 | 96 | FAD, BR |
| 2 | 833 | 0.82 | 0.84 | 107 | FAD, BR |
| 3 | 815 | 0.81 | 0.84 | 98 | FAD, BR |
| 4 | 556 | 0.80 | 0.86 | 81 | FAD, BR |
| 5 | 696 | 0.77 | 0.82 | 77 | empty |
Interfaces
6 interfaces between chains.
- A–D · 1780 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 1658 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1310 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 1296 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 1026 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 4TM3 · Kutzneria sp. 744 ornithine N-hydroxylase, KtzI-FADox-Br · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A8CF85
- Elsewhere: RCSB PDB 4TM3 · PDBe 4TM3 · UniProt A8CF85
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