Research workbench
Gephe in complex with a GABA receptor ALPHA3 subunit derived double mutant peptide in space group P61
Analyse Gephe in complex with a GABA receptor ALPHA3 subunit derived double mutant… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4TK4
- Type
- protein
- Length
- 837 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gephyrin; Gamma-aminobutyric acid receptor subunit alpha-3
- EC
- 2.7.7.75, 2.10.1.1
- UniProt
- Q03555, P20236
- Pockets
- 3 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gephyrin (EC 2.7.7.75, 2.10.1.1) | protein | 413 | 20% helix, 33% strand | Q03555 |
| B | Gephyrin (EC 2.7.7.75, 2.10.1.1) | protein | 406 | 20% helix, 34% strand | Q03555 |
| C, D | Gamma-aminobutyric acid receptor subunit alpha-3 | protein | 9 | 0% helix, 0% strand | P20236 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1059 | 0.82 | 0.83 | 114 | empty |
| 2 | 932 | 0.80 | 0.82 | 89 | empty |
| 3 | 840 | 0.79 | 0.82 | 87 | empty |
Interfaces
5 interfaces between chains.
- A–B · 3400 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 647 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 623 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 90 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 66 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4TK4 · GephE in complex with a GABA receptor alpha3 subunit derived double mutant peptide in… · the same entry in another collection · chain D against D, TM-score 1.00
- Q03555 · AlphaFold monomer V2.0 prediction for gephyrin (Q03555) · a predicted model of the same protein · chain B against A, TM-score 0.96
- P20236 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-3… · a predicted model of the same protein · chain D against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03555
- Every structure of UniProt P20236
- Elsewhere: RCSB PDB 4TK4 · PDBe 4TK4 · UniProt Q03555 · UniProt P20236
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