Research workbench
C-terminal mutant (D559E) of HCV/J4 RNA polymerase
Analyse C-terminal mutant (D559E) of HCV/J4 RNA polymerase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RY7
- Type
- protein
- Length
- 1,130 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HCV J4 RNA polymerase (NS5B)
- EC
- 2.7.7.48
- UniProt
- O92972
- Pockets
- 10 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | HCV J4 RNA polymerase (NS5B) (EC 2.7.7.48) | protein | 565 | 47% helix, 15% strand | O92972 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1016 | 0.80 | 0.81 | 92 | empty |
| 2 | 1053 | 0.80 | 0.81 | 88 | empty |
| 3 | 572 | 0.65 | 0.76 | 49 | empty |
| 4 | 252 | 0.50 | 0.74 | 35 | empty |
| 5 | 130 | 0.48 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 328 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4RY7 · C-terminal mutant (D559E) of HCV/J4 RNA polymerase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O92972
- Elsewhere: RCSB PDB 4RY7 · PDBe 4RY7 · UniProt O92972
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