Research workbench
Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M), apo
Analyse Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M), apo in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RWI
- Type
- protein
- Length
- 585 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor receptor 1
- EC
- 2.7.10.1
- UniProt
- P11362
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 305 | 36% helix, 14% strand | P11362 |
| B | Fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 280 | 40% helix, 16% strand | P11362 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 888 | 0.76 | 0.79 | 63 | empty |
| 2 | 681 | 0.68 | 0.76 | 88 | empty |
| 3 | 315 | 0.59 | 0.77 | 33 | empty |
| 4 | 61 | 0.31 | 0.76 | 15 | empty |
| 5 | 53 | 0.25 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 320 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 4RWI · Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M), apo · the same entry in another collection · chain A against A, TM-score 1.00
- P11362 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 1 (P11362) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11362
- Elsewhere: RCSB PDB 4RWI · PDBe 4RWI · UniProt P11362
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.