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Crystal structure of the green fluorescent variant, nowgfp, of the cyan cerulean at pH 9.0

Analyse Crystal structure of the green fluorescent variant, nowgfp, of the cyan… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4RTC
Type: protein
Length: 227 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nowgfp
Ligands: CRF
Pockets: 2 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nowgfp	protein	227	12% helix, 52% strand	—

Ligands and binding sites

CRF · [(4Z)-2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(1H-indol-3-ylmethylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid · ligand · chains A
GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	174	0.81	0.96	28	CRF
2	58	0.35	0.78	18	empty

Modifications

Observed in the structure: 2 covalent (covalent ligand).

Compared structures

4RTC · Crystal structure of the green fluorescent variant, nowGFP, of the cyan Cerulean at pH 9.0 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4RTC · PDBe 4RTC

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