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Ligand · CRF

CRF · [(4Z)-2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(1H-indol-3-ylmethylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid

CRF, [(4Z)-2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(1H-indol-3-ylmethylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid (C17 H18 N4 O4, 342.4 g/mol), in the MolNFT structures on GenesisL1: bound in 7 records (7 PDB entries). Every…

Component
CRF
Formula
C17 H18 N4 O4
Class
ligand
Structures
7
PDB entries
7

Binding sites

CRF in 7 structures; the first of them:

  • 5T3I · Cyan fluorescence protein soaked with selenourea for 5 min · CRF A66 · binds LEU44, PHE46, VAL61, THR62, THR63, LEU64, VAL68, GLN69 and 13 more
  • 6GEL · The structure of twitch-2B · CRF A66 · binds LEU43, VAL62, THR63, THR64, LEU65, VAL69, GLN70, GLN95 and 12 more
  • 6GEZ · The structure of twitch-2B N532F · CRF A66 · binds LEU43, LEU45, VAL62, THR63, THR64, LEU65, VAL69, GLN70 and 13 more
  • 6QQ8 · Cryogenic temperature structure of the fluorescent protein cerulean recorded after an… · CRF A66 · binds LEU42, LEU44, VAL61, THR62, THR63, LEU64, VAL68, GLN69 and 13 more
  • 6QQ9 · Cryogenic temperature structure of the fluorescent protein cerulean recorded after an… · CRF A66 · binds LEU44, PHE46, VAL61, THR62, THR63, LEU64, VAL68, GLN69 and 13 more
  • 6QQA · Room temperature structure of the fluorescent protein cerulean recorded after an… · CRF A66 · binds LEU42, VAL61, THR62, THR63, LEU64, VAL68, GLN69, GLN94 and 11 more
  • 6QQB · Room temperature structure of the fluorescent protein cerulean recorded after an… · CRF A66 · binds LEU42, VAL61, THR62, THR63, LEU64, VAL68, GLN69, GLN94 and 11 more

Residues it binds most

VAL 9, LEU 9, THR 9, GLN 9, PHE 9, ARG 9, ASN 9, GLU 9, SER 9, ILE 5 (residue and the binding sites it lines).

Found with

  • CR2 · {(4Z)-2-(aminomethyl)-4-[(4-hydroxyphenyl)methylidene]-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid
  • CA · Calcium ion
  • FMT · Formic acid
  • SEY · selenourea
  • CO2 · Carbon dioxide
  • PO4 · Phosphate ion
  • GOL · Glycerol
  • PG4 · Tetraethylene glycol

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