Research workbench
Pyrococcus furiosus smc hinge domain with an extended coiled coil
Analyse Pyrococcus furiosus smc hinge domain with an extended coiled coil in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RSJ
- Type
- protein
- Length
- 1,064 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromosome partition protein smc
- UniProt
- Q8TZY2
- Pockets
- 8 · best druggability 0.82
Structure
x-ray diffraction · 4 distinct chains · 60% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromosome partition protein smc | protein | 270 | 63% helix, 11% strand | Q8TZY2 |
| B | Chromosome partition protein smc | protein | 266 | 58% helix, 12% strand | Q8TZY2 |
| C | Chromosome partition protein smc | protein | 265 | 61% helix, 13% strand | Q8TZY2 |
| D | Chromosome partition protein smc | protein | 263 | 57% helix, 11% strand | Q8TZY2 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 973 | 0.82 | 0.84 | 84 | empty |
| 2 | 932 | 0.82 | 0.84 | 84 | empty |
| 3 | 247 | 0.53 | 0.76 | 34 | empty |
| 4 | 86 | 0.51 | 0.83 | 17 | empty |
| 5 | 101 | 0.37 | 0.74 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2434 Ų buried · 28 hydrogen bonds · protein-protein
- C–D · 2081 Ų buried · 28 hydrogen bonds · protein-protein
- A–D · 308 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4RSJ · Pyrococcus furiosus Smc hinge domain with an extended coiled coil · the same entry in another collection · chain D against D, TM-score 1.00
- Q8TZY2 · AlphaFold monomer V2.0 prediction for chromosome partition protein smc (Q8TZY2) · a predicted model of the same protein · chain D against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TZY2
- Elsewhere: RCSB PDB 4RSJ · PDBe 4RSJ · UniProt Q8TZY2
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