Research workbench
Yeast SMC2-SMC4 hinge domain with extended coiled coils
Analyse Yeast SMC2-SMC4 hinge domain with extended coiled coils in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RSI
- Type
- protein
- Length
- 669 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosomes protein 2; Structural maintenance of chromosomes…
- UniProt
- P38989, Q12267
- Ligands
- PO4
- Pockets
- 8 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 61% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Structural maintenance of chromosomes protein 2 | protein | 283 | 53% helix, 12% strand | P38989 |
| B | Structural maintenance of chromosomes protein 4 | protein | 386 | 66% helix, 8% strand | Q12267 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 477 | 0.73 | 0.82 | 58 | PO4 |
| 2 | 355 | 0.65 | 0.80 | 31 | empty |
| 3 | 294 | 0.61 | 0.79 | 37 | PO4 |
| 4 | 126 | 0.48 | 0.79 | 18 | empty |
| 5 | 96 | 0.44 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 2521 Ų buried · 35 hydrogen bonds · protein-protein
Compared structures
- 4RSI · Yeast Smc2-Smc4 hinge domain with extended coiled coils · the same entry in another collection · chain A against A, TM-score 1.00
- P38989 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 2… · a predicted model of the same protein · chain A against A, TM-score 0.93
- Q12267 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 4… · a predicted model of the same protein · chain B against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38989
- Every structure of UniProt Q12267
- Elsewhere: RCSB PDB 4RSI · PDBe 4RSI · UniProt P38989 · UniProt Q12267
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