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Crystal structure of mthk gating ring in a ligand-free form

Analyse Crystal structure of mthk gating ring in a ligand-free form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4RO0
Type: protein
Length: 8,840 residues
Chains: 40
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcium-gated potassium channel mthk
UniProt: O27564
Pockets: 20 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, a, B, b, C, c, D, d, E, e, F, f, G, g, H, h, I, i, J, j, K, k, L, l, M, m, N, n, O, o, P, p, Q, q, R, r, S, s, T, t	Calcium-gated potassium channel mthk	protein	221	38% helix, 23% strand	O27564

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	649	0.77	0.83	75	empty
2	481	0.77	0.85	45	empty
3	1157	0.76	0.79	154	empty
4	892	0.75	0.79	72	empty
5	881	0.74	0.79	114	empty

Interfaces

95 interfaces between chains.

J–j · 3810 Å² buried · 60 hydrogen bonds · protein-protein
Q–q · 3783 Å² buried · 51 hydrogen bonds · protein-protein
K–k · 3776 Å² buried · 54 hydrogen bonds · protein-protein
I–i · 3766 Å² buried · 50 hydrogen bonds · protein-protein
M–m · 3761 Å² buried · 55 hydrogen bonds · protein-protein

Compared structures

4RO0 · Crystal structure of MthK gating ring in a ligand-free form · the same entry in another collection · chain a against a, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O27564
Elsewhere: RCSB PDB 4RO0 · PDBe 4RO0 · UniProt O27564

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