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Crystal structure analysis of mtb pepck without MN+2

Analyse Crystal structure analysis of mtb pepck without MN+2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4RCG
Type: protein
Length: 592 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoenolpyruvate carboxykinase [GTP]
EC: 4.1.1.32
UniProt: I6Y334
Ligands: GDP, MG
Pockets: 9 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32)	protein	592	32% helix, 22% strand	I6Y334

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A
PEG · Di(hydroxyethyl)ether · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	78	0.77	0.99	17	empty
2	662	0.72	0.79	76	GDP, MG
3	171	0.62	0.84	22	PEG
4	144	0.55	0.81	21	empty
5	94	0.36	0.75	18	PEG

Compared structures

4RCG · Crystal Structure Analysis of MTB PEPCK without Mn+2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I6Y334
Elsewhere: RCSB PDB 4RCG · PDBe 4RCG · UniProt I6Y334

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