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A regulatory domain of an ion channel

Analyse A regulatory domain of an ion channel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4RAX
Type: protein
Length: 227 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Piezo-type mechanosensitive ion channel component 1
UniProt: E2JF22
Pockets: 1 · best druggability 0.29

Structure

x-ray diffraction · 1 distinct chain · 22% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Piezo-type mechanosensitive ion channel component 1	protein	227	22% helix, 38% strand	E2JF22

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.29	0.73	14	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4RAX · A regulatory domain of an ion channel · the same entry in another collection · chain A against A, TM-score 1.00
E2JF22 · AlphaFold monomer V2.0 prediction for piezo-type mechanosensitive ion channel component 1… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E2JF22
Elsewhere: RCSB PDB 4RAX · PDBe 4RAX · UniProt E2JF22

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