Research workbench
Crystal structure of peroxisomal acyl-CoA oxidase-II from rat liver
Analyse Crystal structure of peroxisomal acyl-CoA oxidase-II from rat liver in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1IS2
- Type
- protein
- Length
- 1,266 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acyl-CoA oxidase
- EC
- 1.3.3.6
- UniProt
- P07872
- Ligands
- FAD
- Pockets
- 10 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acyl-CoA oxidase (EC 1.3.3.6) | protein | 637 | 60% helix, 11% strand | P07872 |
| B | Acyl-CoA oxidase (EC 1.3.3.6) | protein | 629 | 60% helix, 10% strand | P07872 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1002 | 0.87 | 0.88 | 114 | FAD |
| 2 | 1147 | 0.86 | 0.87 | 122 | FAD |
| 3 | 911 | 0.85 | 0.87 | 99 | empty |
| 4 | 334 | 0.77 | 0.88 | 48 | empty |
| 5 | 196 | 0.56 | 0.80 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 5132 Ų buried · 72 hydrogen bonds · protein-protein
Compared structures
- 1IS2 · Crystal Structure of Peroxisomal Acyl-CoA Oxidase-II from Rat Liver · the same entry in another collection · chain A against A, TM-score 1.00
- P07872 · AlphaFold monomer V2.0 prediction for peroxisomal acyl-coenzyme a oxidase 1 (P07872) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07872
- Elsewhere: RCSB PDB 1IS2 · PDBe 1IS2 · UniProt P07872
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