Crystal structure of human BAZ2B bromodomain in complex with a diacetylated histone 4 peptide (H4K8ACK12AC)

Structure

x-ray diffraction · 2 distinct chains · 61% helix, 0% strand (DSSP).

Ligands and binding sites

• EDO · 1,2-ethanediol · additive · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

3 interfaces between chains.

• A–B · 331 Ų buried · 4 hydrogen bonds · protein-protein
• A–C · 305 Ų buried · 2 hydrogen bonds · protein-protein
• B–C · 295 Ų buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (acetylation).

Compared structures

• 4QC3 · Crystal structure of human BAZ2B bromodomain in complex with a diacetylated histone 4… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9UIF8 · AlphaFold monomer V2.0 prediction for bromodomain adjacent to zinc finger domain protein… · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9UIF8
• Elsewhere: RCSB PDB 4QC3 · PDBe 4QC3 · UniProt Q9UIF8