Research workbench

The solution structure of the F42A mutant of human interleukin 2

Analyse The solution structure of the F42A mutant of human interleukin 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IRL
Type: protein
Length: 133 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-2
UniProt: P60568
Pockets: 2 · best druggability 0.47

Structure

solution nmr · 1 distinct chain · 52% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-2	protein	133	52% helix, 3% strand	P60568

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.47	0.81	14	empty
2	51	0.33	0.78	12	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1IRL · The solution structure of the F42A mutant of human interleukin 2 · the same entry in another collection · chain A against A, TM-score 1.00
P60568 · AlphaFold monomer V2.0 prediction for interleukin-2 (P60568) · a predicted model of the same protein · chain A against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P60568
Elsewhere: RCSB PDB 1IRL · PDBe 1IRL · UniProt P60568

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.