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Crystal structure of the human glucose transporter GLUT1

Analyse Crystal structure of the human glucose transporter GLUT1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4PYP
Type: protein
Length: 447 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Solute carrier family 2, facilitated glucose transporter member 1
UniProt: P11166
Ligands: BNG
Pockets: 3 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 79% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Solute carrier family 2, facilitated glucose transporter member 1	protein	447	79% helix, 0% strand	P11166

Ligands and binding sites

BNG · nonyl beta-D-glucopyranoside · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1070	0.80	0.81	72	BNG
2	109	0.43	0.78	23	empty
3	54	0.39	0.80	12	empty

Compared structures

4PYP · Crystal structure of the human glucose transporter GLUT1 · the same entry in another collection · chain A against A, TM-score 1.00
P11166 · AlphaFold monomer V2.0 prediction for solute carrier family 2, facilitated glucose… · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11166
Elsewhere: RCSB PDB 4PYP · PDBe 4PYP · UniProt P11166

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