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Translation initiation factor EIF4E in complex with M7GDP, NMR, 20 structures

Analyse Translation initiation factor EIF4E in complex with M7GDP, NMR, 20 structures in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1AP8
Type: protein
Length: 213 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Translation initiation factor EIF4E
UniProt: P07260
Ligands: M7G
Pockets: 1 · best druggability 0.28

Structure

solution nmr · 1 distinct chain · 21% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Translation initiation factor EIF4E	protein	213	21% helix, 23% strand	P07260

Ligands and binding sites

M7G · 7N-methyl-8-hydroguanosine-5'-diphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.28	0.73	14	M7G

Compared structures

1AP8 · Translation initiation factor EIF4E in complex with M7GDP, NMR, 20 structures · the same entry in another collection · chain A against A, TM-score 1.00
P07260 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P07260) · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07260
Elsewhere: RCSB PDB 1AP8 · PDBe 1AP8 · UniProt P07260

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