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Crystal structures of designed armadillo repeat proteins: implications of construct design and crystallization conditions on overall structure.

Analyse Crystal structures of designed armadillo repeat proteins: implications of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4PLR
Type: protein
Length: 578 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ARM00008
Ligands: CA
Pockets: 2 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	ARM00008	protein	289	73% helix, 0% strand	—

Ligands and binding sites

CA · Calcium ion · metal · 8 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	965	0.75	0.78	112	CA
2	62	0.32	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 1402 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

4PLR · Crystal Structures of Designed Armadillo Repeat Proteins: Implications of Construct… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4PLR · PDBe 4PLR

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