Research workbench
Dicty myosin II R238E.E459R mutant (with ADP.PI) in the pi release state
Analyse Dicty myosin II R238E.E459R mutant (with ADP.PI) in the pi release state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4PJK
- Type
- protein
- Length
- 713 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-2 heavy chain
- EC
- 3.6.4.1
- UniProt
- P08799
- Ligands
- ADP, MG, PO4
- Pockets
- 7 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin-2 heavy chain (EC 3.6.4.1) | protein | 713 | 45% helix, 16% strand | P08799 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- PO4 · Phosphate ion · ion · 2 copies · chains A
- GOL · Glycerol · additive · 7 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1094 | 0.77 | 0.80 | 93 | GOL |
| 2 | 385 | 0.65 | 0.79 | 54 | MG, ADP, PO4, GOL |
| 3 | 166 | 0.60 | 0.83 | 31 | PO4, GOL |
| 4 | 284 | 0.56 | 0.76 | 31 | empty |
| 5 | 85 | 0.36 | 0.75 | 17 | empty |
Compared structures
- 4PJK · Dicty myosin II R238E.E459R mutant (with ADP.Pi) in the Pi release state · the same entry in another collection · chain A against A, TM-score 1.00
- P08799 · AlphaFold monomer V2.0 prediction for myosin-2 heavy chain (P08799) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08799
- Elsewhere: RCSB PDB 4PJK · PDBe 4PJK · UniProt P08799
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.