Research workbench
Thermophilic cytochrome P450 (CYP119) from sulfolobus solfataricus: high resolution structural origin of its thermostability and functional properties
Analyse Thermophilic cytochrome P450 (CYP119) from sulfolobus solfataricus: high… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1IO9
- Type
- protein
- Length
- 720 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome P450 CYP119
- EC
- 1.14.14.-
- UniProt
- Q55080
- Ligands
- HEM
- Pockets
- 8 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytochrome P450 CYP119 (EC 1.14.14.-) | protein | 366 | 51% helix, 12% strand | Q55080 |
| B | Cytochrome P450 CYP119 (EC 1.14.14.-) | protein | 354 | 50% helix, 12% strand | Q55080 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 710 | 0.82 | 0.85 | 68 | HEM |
| 2 | 692 | 0.79 | 0.83 | 56 | HEM |
| 3 | 866 | 0.73 | 0.77 | 67 | empty |
| 4 | 195 | 0.52 | 0.77 | 27 | empty |
| 5 | 71 | 0.41 | 0.80 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 278 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 1IO9 · Thermophilic cytochrome P450 (CYP119) from sulfolobus solfataricus: high resolution… · the same entry in another collection · chain A against A, TM-score 1.00
- Q55080 · AlphaFold monomer V2.0 prediction for cytochrome P450 119 (Q55080) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q55080
- Elsewhere: RCSB PDB 1IO9 · PDBe 1IO9 · UniProt Q55080
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.