Research workbench
The molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 ångströms resolution
Analyse The molecular and crystal structures of monoclinic porcine pepsin refined at… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4PEP
- Type
- protein
- Length
- 326 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pepsin
- EC
- 3.4.23.1
- UniProt
- P00791
- Pockets
- 2 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 15% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pepsin (EC 3.4.23.1) | protein | 326 | 15% helix, 46% strand | P00791 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 281 | 0.63 | 0.80 | 40 | empty |
| 2 | 84 | 0.34 | 0.75 | 17 | empty |
Modifications
Observed in the structure: 3 disulfide, 1 modified (disulfide, phosphorylation).
Compared structures
- 4PEP · The molecular and crystal structures of monoclinic porcine pepsin refined at 1.8… · the same entry in another collection · chain A against A, TM-score 1.00
- P00791 · AlphaFold monomer V2.0 prediction for pepsin a (P00791) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00791
- Elsewhere: RCSB PDB 4PEP · PDBe 4PEP · UniProt P00791
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