UniProt P00791
Pepsin A (P00791)
Pepsin A (UniProt P00791), EC 3.4.23.1: 21 experimental structures on GenesisL1, 4 ligands bound, 2 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P00791
- Protein
- Pepsin A
- EC
- 3.4.23.1
- Experimental structures
- 21
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 2 · 2 records with a druggable one
Structures
21 records of P00791 in the MolNFT archive: 21 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F34 | Crystal structure of ascaris pepsin inhibitor-3 bound to porcine pepsin | x-ray diffraction | A | — | — |
| 1F34 | Crystal structure of ascaris pepsin inhibitor-3 bound to porcine pepsin | x-ray diffraction | A | — | — |
| 1PSA | Structure of a PEPSIN(SLASH)RENIN inhibitor complex reveals a novel crystal packing induced by… | x-ray diffraction | A, B | — | — |
| 1PSA | Structure of a PEPSIN(SLASH)RENIN inhibitor complex reveals a novel crystal packing induced by… | x-ray diffraction | A, B | — | — |
| 2PSG | Refined structure of porcine pepsinogen at 1.8 ångströms resolution | x-ray diffraction | A | — | — |
| 2PSG | Refined structure of porcine pepsinogen at 1.8 ångströms resolution | x-ray diffraction | A | — | — |
| 3PEP | Revised 2.3 ångströms structure of porcine pepsin. evidence for a flexible subdomain | x-ray diffraction | A | — | — |
| 3PEP | Revised 2.3 ångströms structure of porcine pepsin. evidence for a flexible subdomain | x-ray diffraction | A | — | — |
| 3PSG | The high resolution crystal structure of porcine pepsinogen | x-ray diffraction | A | — | — |
| 3PSG | The high resolution crystal structure of porcine pepsinogen | x-ray diffraction | A | — | — |
| 4PEP | The molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 ångströms… | x-ray diffraction | A | — | — |
| 4PEP | The molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 ångströms… | x-ray diffraction | A | — | — |
| 5PEP | X-ray analyses of aspartic proteases. II. three-dimensional structure of the hexagonal crystal form… | x-ray diffraction | A | — | — |
| 5PEP | X-ray analyses of aspartic proteases. II. three-dimensional structure of the hexagonal crystal form… | x-ray diffraction | A | — | — |
| 6XCT | Porcine pepsin in complex with amprenavir | x-ray diffraction | A | 478 | — |
| 6XCY | Porcine pepsin in complex with ritonavir | x-ray diffraction | A | RIT | — |
| 6XCZ | Porcine pepsin in complex with saquinavir | x-ray diffraction | A | ROC | 1 (best 0.67) |
| 6XCZ | Porcine pepsin in complex with saquinavir | x-ray diffraction | A | — | — |
| 6XD2 | Porcine pepsin in complex with darunavir | x-ray diffraction | A | 017 | 1 (best 0.64) |
| 6XD2 | Porcine pepsin in complex with darunavir | x-ray diffraction | A | 017 | — |
| P00791 | AlphaFold monomer V2.0 prediction for pepsin a (P00791) | — | — | — |
Ligands
- 017 · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl(1s,2r)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate · in 2 records
- 478 · {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid tetrahydro-furan-3-yl ester · in 1 record
- RIT · Ritonavir · in 1 record
- ROC · (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide · in 1 record
Elsewhere
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