Research workbench
Human phenylalanine hydroxylase catalytic domain dimer with bound nor- adrenaline inhibitor
Analyse Human phenylalanine hydroxylase catalytic domain dimer with bound nor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4PAH
- Type
- protein
- Length
- 308 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phenylalanine hydroxylase
- EC
- 1.14.16.1
- UniProt
- P00439
- Ligands
- LNR, FE
- Pockets
- 1 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phenylalanine hydroxylase (EC 1.14.16.1) | protein | 308 | 50% helix, 13% strand | P00439 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 605 | 0.71 | 0.79 | 59 | FE, LNR |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4PAH · Human phenylalanine hydroxylase catalytic domain dimer with bound nor-adrenaline inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
- P00439 · AlphaFold monomer V2.0 prediction for phenylalanine-4-hydroxylase (P00439) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00439
- Elsewhere: RCSB PDB 4PAH · PDBe 4PAH · UniProt P00439
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