Research workbench
Tl+-bound inward-facing state (bound conformation) of the glutamate transporter homologue gltph
Analyse Tl+-bound inward-facing state (bound conformation) of the glutamate transporter… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4P6H
- Type
- protein
- Length
- 1,230 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gltph
- UniProt
- O59010
- Ligands
- TL, HG
- Pockets
- 18 · best druggability 0.87
Structure
x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Gltph | protein | 410 | 73% helix, 0% strand | O59010 |
Ligands and binding sites
- TL · Thallium (I) ion · metal · 6 copies · chains A, B, C
- HG · Mercury (II) ion · metal · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
18 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 801 | 0.87 | 0.89 | 57 | empty |
| 2 | 60 | 0.73 | 0.98 | 20 | empty |
| 3 | 701 | 0.72 | 0.78 | 87 | HG |
| 4 | 455 | 0.67 | 0.79 | 66 | empty |
| 5 | 341 | 0.63 | 0.79 | 42 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1060 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 1030 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 1025 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4P6H · Tl+-bound inward-facing state (bound conformation) of the glutamate transporter homologue… · the same entry in another collection · chain A against A, TM-score 1.00
- O59010 · AlphaFold monomer V2.0 prediction for glutamate transporter homolog (O59010) · a predicted model of the same protein · chain A against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O59010
- Elsewhere: RCSB PDB 4P6H · PDBe 4P6H · UniProt O59010
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