Research workbench
Apo inward-facing state of the glutamate transporter homologue gltph in alkali-free conditions
Analyse Apo inward-facing state of the glutamate transporter homologue gltph in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4P3J
- Type
- protein
- Length
- 1,230 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gltph
- UniProt
- O59010
- Ligands
- HG
- Pockets
- 20 · best druggability 0.88
Structure
x-ray diffraction · 3 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gltph | protein | 411 | 78% helix, 0% strand | O59010 |
| B | Gltph | protein | 408 | 78% helix, 0% strand | O59010 |
| C | Gltph | protein | 411 | 78% helix, 0% strand | O59010 |
Ligands and binding sites
- HG · Mercury (II) ion · metal · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 658 | 0.88 | 0.92 | 42 | empty |
| 2 | 539 | 0.67 | 0.77 | 52 | empty |
| 3 | 463 | 0.64 | 0.77 | 55 | empty |
| 4 | 445 | 0.63 | 0.77 | 55 | empty |
| 5 | 248 | 0.59 | 0.79 | 28 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1182 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 1143 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 1136 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4P3J · Apo inward-facing state of the glutamate transporter homologue GltPh in alkali-free… · the same entry in another collection · chain A against A, TM-score 1.00
- O59010 · AlphaFold monomer V2.0 prediction for glutamate transporter homolog (O59010) · a predicted model of the same protein · chain A against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O59010
- Elsewhere: RCSB PDB 4P3J · PDBe 4P3J · UniProt O59010
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