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Structure of influenza B PB2 cap-binding domain with Q325F mutation complex with GDP

Analyse Structure of influenza B PB2 cap-binding domain with Q325F mutation complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4OR6
Type: protein
Length: 325 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polymerase basic protein 2
Ligands: GDP
Pockets: 3 · best druggability 0.37

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polymerase basic protein 2	protein	163	23% helix, 42% strand	—
B	Polymerase basic protein 2	protein	162	23% helix, 41% strand	—

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	88	0.37	0.75	18	GDP
2	89	0.37	0.75	18	GDP
3	68	0.30	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 416 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

4OR6 · Structure of Influenza B PB2 cap-binding domain with Q325F mutation complex with GDP · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4OR6 · PDBe 4OR6

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