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Human interleukin-6, NMR, minimized average structure

Analyse Human interleukin-6, NMR, minimized average structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IL6
Type: protein
Length: 166 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-6
UniProt: P05231
Pockets: 3 · best druggability 0.32

Structure

solution nmr · 1 distinct chain · 65% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-6	protein	166	65% helix, 0% strand	P05231

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	68	0.32	0.75	13	empty
2	87	0.32	0.73	16	empty
3	52	0.28	0.75	11	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1IL6 · Human interleukin-6, NMR, minimized average structure · the same entry in another collection · chain A against A, TM-score 1.00
P05231 · AlphaFold monomer V2.0 prediction for interleukin-6 (P05231) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05231
Elsewhere: RCSB PDB 1IL6 · PDBe 1IL6 · UniProt P05231

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