Research workbench
The PSEUDOKINASE/KINASE protein from JAK-family member TYK2
Analyse The PSEUDOKINASE/KINASE protein from JAK-family member TYK2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OLI
- Type
- protein
- Length
- 539 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-receptor tyrosine-protein kinase TYK2
- EC
- 2.7.10.2
- UniProt
- P29597
- Ligands
- 2TT
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | protein | 539 | 39% helix, 19% strand | P29597 |
Ligands and binding sites
- 2TT · 2-chloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 325 | 0.69 | 0.83 | 39 | 2TT |
| 2 | 349 | 0.67 | 0.81 | 40 | 2TT |
| 3 | 259 | 0.63 | 0.81 | 40 | empty |
| 4 | 123 | 0.42 | 0.76 | 25 | empty |
| 5 | 107 | 0.38 | 0.75 | 19 | empty |
Compared structures
- 4OLI · The pseudokinase/kinase protein from JAK-family member TYK2 · the same entry in another collection · chain A against A, TM-score 1.00
- P29597 · AlphaFold monomer V2.0 prediction for non-receptor tyrosine-protein kinase TYK2 (P29597) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29597
- Elsewhere: RCSB PDB 4OLI · PDBe 4OLI · UniProt P29597
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