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Crystal structure of human ARGONAUTE2
Analyse Crystal structure of human ARGONAUTE2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OLA
- Type
- protein + RNA
- Length
- 798 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein argonaute-2; 5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*U)-3'
- EC
- 3.1.26.-
- UniProt
- Q9UKV8
- Ligands
- IPH
- Pockets
- 4 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein argonaute-2 (EC 3.1.26.-) | protein | 789 | 30% helix, 29% strand | Q9UKV8 |
| B | 5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*U)-3' | rna | 9 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 950 | 0.80 | 0.82 | 91 | empty |
| 2 | 99 | 0.44 | 0.79 | 20 | empty |
| 3 | 85 | 0.38 | 0.77 | 22 | empty |
| 4 | 77 | 0.36 | 0.77 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1567 Ų buried · 43 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UKV8
- Elsewhere: RCSB PDB 4OLA · PDBe 4OLA · UniProt Q9UKV8
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