Research workbench
Crystal structure of the HIV-1 integrase catalytic domain with GSK1264
Analyse Crystal structure of the HIV-1 integrase catalytic domain with GSK1264 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OJR
- Type
- protein
- Length
- 131 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HIV-1 integrase
- UniProt
- P03366
- Ligands
- 2SQ, SO4
Structure
x-ray diffraction · 1 distinct chain · 55% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HIV-1 integrase | protein | 131 | 55% helix, 21% strand | P03366 |
Ligands and binding sites
- 2SQ · (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid · ligand · chains A
- SO4 · Sulfate ion · ion · chains A
- CAC · Cacodylate ion · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 4OJR · Crystal Structure of the HIV-1 Integrase catalytic domain with GSK1264 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03366
- Elsewhere: RCSB PDB 4OJR · PDBe 4OJR · UniProt P03366
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