Research workbench
Leopard syndrome-associated SHP2/Q510E mutant
Analyse Leopard syndrome-associated SHP2/Q510E mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OHI
- Type
- protein
- Length
- 502 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 11
- EC
- 3.1.3.48
- UniProt
- Q06124
- Pockets
- 6 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) | protein | 502 | 30% helix, 26% strand | Q06124 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 393 | 0.68 | 0.81 | 39 | empty |
| 2 | 121 | 0.46 | 0.79 | 33 | empty |
| 3 | 87 | 0.39 | 0.77 | 19 | empty |
| 4 | 80 | 0.31 | 0.73 | 18 | empty |
| 5 | 60 | 0.29 | 0.75 | 13 | empty |
Compared structures
- 4OHI · LEOPARD Syndrome-Associated SHP2/Q510E mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06124
- Elsewhere: RCSB PDB 4OHI · PDBe 4OHI · UniProt Q06124
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