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Crystal structure of the human MST1-RASSF5 sarah heterodimer

Analyse Crystal structure of the human MST1-RASSF5 sarah heterodimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4OH8
Type: protein
Length: 89 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase 4; RAS association domain-containing protein 5
EC: 2.7.11.1
UniProt: Q13043, Q8WWW0

Structure

x-ray diffraction · 2 distinct chains · 92% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase 4 (EC 2.7.11.1)	protein	43	95% helix, 0% strand	Q13043
B	RAS association domain-containing protein 5	protein	46	89% helix, 0% strand	Q8WWW0

Interfaces

1 interface between chains.

A–B · 1240 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

4OH8 · Crystal Structure of the human MST1-RASSF5 SARAH heterodimer · the same entry in another collection · chain A against A, TM-score 1.00
Q8WWW0 · AlphaFold monomer V2.0 prediction for RAS association domain- containing protein 5… · a predicted model of the same protein · chain B against A, TM-score 0.91
Q13043 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase 4 (Q13043) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13043
Every structure of UniProt Q8WWW0
Elsewhere: RCSB PDB 4OH8 · PDBe 4OH8 · UniProt Q13043 · UniProt Q8WWW0

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