UniProt Q13043
Serine/threonine-protein kinase 4 (Q13043)
Serine/threonine-protein kinase 4 (UniProt Q13043), EC 2.7.11.1: 14 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q13043
- Protein
- Serine/threonine-protein kinase 4
- EC
- 2.7.11.1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 26 · 6 records with a druggable one
Structures
15 records of Q13043 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JO8 | Solution structure of C-terminal domain of human mammalian sterile 20-like kinase 1 (MST1) | solution nmr | A, B | — | — |
| 2JO8 | Solution structure of C-terminal domain of human mammalian sterile 20- like kinase 1 (MST1) | solution nmr | A, B | — | — |
| 3COM | Crystal structure of Mst1 kinase | x-ray diffraction | A, B | — | 4 (best 0.62) |
| 3COM | Crystal structure of MST1 kinase | x-ray diffraction | A, B | — | — |
| 4NR2 | Crystal structure of STK4 (MST1) SARAH domain | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4NR2 | Crystal structure of STK4 (MST1) sarah domain | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4OH8 | Crystal Structure of the human MST1-RASSF5 SARAH heterodimer | x-ray diffraction | A | — | — |
| 4OH8 | Crystal structure of the human MST1-RASSF5 sarah heterodimer | x-ray diffraction | A | — | — |
| 6YAT | Crystal structure of STK4 (MST1) in complex with compound 6 | x-ray diffraction | A, B | 3FX, OJ5 | 4 (best 0.70) |
| 6YAT | Crystal structure of STK4 (MST1) in complex with compound 6 | x-ray diffraction | A, B | 3FX, OJ5 | — |
| 8A5J | Crystal structure of Human STE20-like kinase 1, MST1 in complex with compound XMU-MP-1 | x-ray diffraction | A, B | 5BS | 3 (best 0.73) |
| 8A5J | Crystal structure of human STE20-like kinase 1, MST1 in complex with compound xmu-mp-1 | x-ray diffraction | A, B | 5BS | — |
| 8PAV | Crystal structure of MST1 with a MAP4K1 SMOL inhibitor | x-ray diffraction | A, B | XOZ | 5 (best 0.65) |
| 8PAW | Crystal structure of MST1 with a MAP4K1 SMOL inhibitor | x-ray diffraction | A, B | ASP, XQL | 5 (best 0.67) |
| Q13043 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase 4 (Q13043) | predicted | A | — | 5 (best 0.77) |
Ligands
- 3FX · (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid · in 2 records
- 5BS · 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide · in 2 records
- OJ5 · 4-[5-(3-chlorophenyl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine · in 2 records
- ASP · Aspartic acid · in 1 record
- XOZ · 1-[3,5-bis(fluoranyl)-4-[[3-(1,3-thiazol-5-yl)-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-3-(2-methoxyethyl)urea · in 1 record
- XQL · 1-[3,5-bis(fluoranyl)-4-[[3-(1-propan-2-ylpyrazol-3-yl)-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-3-(2-methoxyethyl)urea · in 1 record
Experiment against prediction
- 8A5J chain B against the predicted model Q13043: TM-score 0.94, RMSD 1.48 Å
- 8A5J chain B against the predicted model Q13043: TM-score 0.94, RMSD 1.48 Å
- 8A5J chain A against the predicted model Q13043: TM-score 0.93, RMSD 1.62 Å
- 8A5J chain A against the predicted model Q13043: TM-score 0.93, RMSD 1.62 Å
- 8PAV chain B against the predicted model Q13043: TM-score 0.93, RMSD 1.59 Å
- 8PAW chain B against the predicted model Q13043: TM-score 0.93, RMSD 1.62 Å
- 8PAV chain A against the predicted model Q13043: TM-score 0.93, RMSD 1.63 Å
- 3COM chain A against the predicted model Q13043: TM-score 0.93, RMSD 1.61 Å
- 3COM chain A against the predicted model Q13043: TM-score 0.93, RMSD 1.61 Å
- 8PAW chain A against the predicted model Q13043: TM-score 0.93, RMSD 1.62 Å
Elsewhere
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